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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
46.67
Human Site:
Y1029
Identified Species:
73.33
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
Y1029
F
F
E
L
R
L
K
Y
Y
G
L
R
K
E
W
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
Y1058
F
F
D
L
R
L
S
Y
Y
G
L
R
K
E
W
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
Y1044
F
F
D
L
R
L
S
Y
Y
G
L
R
K
E
W
Dog
Lupus familis
XP_537646
1532
174610
Y1029
F
F
E
L
R
L
K
Y
Y
G
L
R
K
E
W
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
Y1028
F
F
E
L
R
L
K
Y
Y
G
L
R
K
E
W
Rat
Rattus norvegicus
P41516
1526
173202
Y1027
F
F
E
L
R
L
K
Y
Y
G
L
R
K
E
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
Y1057
F
F
E
L
R
L
K
Y
Y
G
L
R
K
E
W
Chicken
Gallus gallus
O42130
1553
174974
Y1030
F
F
E
L
R
L
R
Y
Y
G
L
R
K
E
W
Frog
Xenopus laevis
NP_001082502
1579
178601
Y1027
F
F
D
L
R
V
K
Y
Y
S
L
R
K
D
W
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
Y1032
F
F
E
L
R
M
K
Y
Y
V
L
R
K
D
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
Y1011
Y
Y
K
L
R
R
E
Y
Y
A
R
R
R
D
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
K1065
F
Y
D
S
R
Q
E
K
Y
V
Q
R
K
E
Y
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
L1011
L
R
G
E
E
E
G
L
H
K
M
F
K
L
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
Y1019
F
F
D
L
R
F
E
Y
Y
E
K
R
K
E
T
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
V990
K
I
K
K
Y
N
S
V
N
E
I
L
S
E
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
86.6
86.6
100
N.A.
100
100
N.A.
100
93.3
73.3
80
N.A.
33.3
N.A.
40
6.6
P-Site Similarity:
100
93.3
93.3
100
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
80
N.A.
66.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
34
0
0
0
0
0
0
0
0
0
0
20
0
% D
% Glu:
0
0
47
7
7
7
20
0
0
14
0
0
0
74
0
% E
% Phe:
80
74
0
0
0
7
0
0
0
0
0
7
0
0
14
% F
% Gly:
0
0
7
0
0
0
7
0
0
54
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
0
0
0
7
0
0
0
0
% I
% Lys:
7
0
14
7
0
0
47
7
0
7
7
0
87
0
0
% K
% Leu:
7
0
0
80
0
54
0
7
0
0
67
7
0
7
0
% L
% Met:
0
0
0
0
0
7
0
0
0
0
7
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
0
7
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
0
0
0
0
7
0
0
0
7
% Q
% Arg:
0
7
0
0
87
7
7
0
0
0
7
87
7
0
0
% R
% Ser:
0
0
0
7
0
0
20
0
0
7
0
0
7
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% T
% Val:
0
0
0
0
0
7
0
7
0
14
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
67
% W
% Tyr:
7
14
0
0
7
0
0
80
87
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _